Journal CME 41.08: Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa-Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

Introduction

Journal CME 41.08: Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa-Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

Journal CME 41.08

Course Format

Self-Guided

Release Date

August 14, 2026

Expiration Date

August 14, 2027

Program Description

The Journal CME 41.08 article aims to characterize the volumetric and neurometabolic brain changes in GCH1 mutation carriers (MC) and explore their relationship with clinical severity.

Accreditation and Credit Designation

ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

The International Parkinson and Movement Disorder Society designates this activity for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation.

FACULTY DISCLOSURE

All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available HERE. All relevant financial relationships have been mitigated in advance of this program.

METHOD OF PARTICIPATION

Each module will take approximately one (1) hour to complete. Upon reading the article, participants will take a post-test and must receive a grade of 75% or higher to pass. Participants are allowed multiple attempts to complete the post-test. Once the post-test is passed, participants are required to complete the module evaluation.

SATISFACTORY COMPLETION

Participants must complete an evaluation for each session they attend to receive continuing medical education credit. Your chosen session(s) must be attended in their entirety. Partial credit for individual sessions is not available.

CONTENT VALIDITY STATEMENT

All recommendations involving clinical medicine in MDS activities are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the case of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendations conforms to the generally accepted standards of experimental design, data collection and analysis. Activities that promote recommendations, treatment or manners of practicing medicine not within the definition of CME or are knowing to have risks or dangers that outweigh the benefits or are knowing to be ineffective in the treatment of patients do not constitute valid CME.

Contact Us

MDS Education
education@movementdisorders.org

Course Overview

COURSE PURPOSE

Journal CME highlights various articles covering relevant issues, developments and research topics in the area of movement disorders. Articles are selected from Movement Disorders, the official Journal of the International Parkinson and Movement Disorder Society.

LEARNING OBJECTIVES

Upon completion of this activity, learners will be able to:

1. Understand the role of GCH1 and tetrahydrobiopterin in dopamine synthesis

2. Assess the clinical and imaging methods used to characterize GCH1-related DRD

3. Evaluate structural and metabolic changes in the basal ganglia and cerebellum associated with GCH1-related DRD

INTENDED AUDIENCE

This activity is intended for clinicians, other health professionals, researchers, policy makers from throughout the world, both MDS members and non-members, who interact with patients living with Movement Disorders.

HARDWARE AND SOFTWARE REQUIREMENTS

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.

2. Compatible with Windows PC and MAC (256 MB of RAM or higher).

3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher.

4. Adobe Flash Player 12.0 (or higher).

5. Adobe Reader to print certificate.