Marianthi Breza, MD, MSc, PhD Candidate - National & Kapodistrian Univ. of Athens, Panorama Pallinis, Greece

Yury Seliverstov, MD, PhD - Research Center of Neurology, Moscow, Russia

The primary purpose of this course is to provide information on genetics and pathophysiology of Huntington's disease.

Upon completion of this activity learners will be able to:

1. Identify the HD gene defect and describe clinical correlates of the CAG repeat length in Huntington's disease

2. Describe the current understanding of the mechanism leading to Huntington's disease pathogenesis

3. Describe the benefits, limitations, and ethical issues of genetic counseling and testing in Huntington's disease

This activity is intended for neurologists, primary care physicians with an interest in movement disorders, neurology residents and movement disorder fellows.

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.

2. Compatible with Windows PC and MAC (256 MB of RAM or higher)

3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher

4. Adobe Flash Player 12.0 (or higher).

5. Adobe Reader to print certificate.