Course Director

Lorraine Kalia, MD, PhD - University of Toronto, Toronto, Canada

Sheng-Han Kuo, MD - Columbia University, New York, United States 

Faculty

Helen M. Bronte-Stewart, MD, MSE - Stanford University, Stanford, CA, USA

Michael Schlossmacher, MD - The Ottawa Hospital, Ottawa, ON, Canada

Peter K. Todd, MD, PhD - University of Michigan, Ann Arbor, MI, USA

The primary purpose of this course is aimed at addressing the significance of translational research in movement disorders. The primary objectives are to inspire basic scientists to undertake research with direct clinical relevance, and to equip clinicians with the foundational knowledge required to utilize upcoming diagnostic tests and therapies effectively.

The program facilitates collaborative learning between basic scientists and clinicians, encouraging future partnerships in the field of movement disorders. By addressing current hot topics that bridge the gap between the lab and the clinic, this series seeks to foster a collaborative environment that will yield valuable insights and advancements in translational research.

Upon completion of this activity learners will be able to:

1. Recognize examples where basic science research significantly influenced current clinical practices in movement disorders
2. Summarize the mechanisms by which nucleotide repeat expansions lead to various movement disorders and evaluate their potential as targets for treatment
3. Explain the biophysical characteristics of prion-like proteins and their practical application in seeding assays
4. Describe the role of T-type calcium channels in causing essential tremor and assess their potential as treatment targets
5. Demonstrate the utilization of brain oscillations in closed-loop deep brain stimulation techniques