Course Program & Schedule   

Schedule as of July 3, 2024

COURSE VENUE

JW Marriott Hotel Kuala Lumpur

183, Jln Bukit Bintang, Bukit Bintang, 55100

Kuala Lumpur, Malaysia

LEARNING OBJECTIVES

Upon completion of this activity, learners will be able to: 

1. Describe the main genetic mutations associated to PD, as well as their functional and clinical relevance

2. Adapt the knowledge from genetic-based discoveries in PD research and patient care

3. Demonstrate basic skills in choosing genetic tests, performing genetic counselling and interpreting genetic test reports in the care of patients with movement disorders

CERTIFICATE CLAIMING INSTRUCTIONS

Course certificate of attendance are available online. To access:

1. Visit https://education.movementdisorders.org.

2. Click “GET CERTIFICATE” in the upper right corner.

3. Once prompted enter the certificate code 791638. You will be prompted to fill out your course evaluation and upon completion, you will be able to download your certificate of attendance.

Supported in part by the Global Parkinson’s Genetics Program, a program of the Aligning Science Across Parkinson’s initiative and implemented by the Michael J. Fox Foundation 

Pre-Course E-Learning Modules

Please take the time to complete the following e-Learning modules ahead of the in-person course:

1. Genetic Testing 101 (Part A): https://education.movementdisorders.org/Detail/141/Genetic-Testing-101-Part-A?_ga=2.78355796.1777784487.1719418808-932757551.1714879036 
2. Genetic Testing 101 (Part B): https://education.movementdisorders.org/Detail/142/Genetic-Testing-101-Part-B?_ga=2.110819653.1777784487.1719418808-932757551.1714879036 

Practice Session Materials

Practice Session 1

Case Scenarios Handout

Practice Session 2

Case Scenarios Handout

Practice Session 3

Case 1.xlsx

Case 2.xlsx

Case 3.xlsx

Lecture Presentations

Presentations will be uploaded upon submission from faculty members.

DAY 1: Saturday, July 13, 2024

1.01 Introduction to Neurogenetics and Genetic Testing Platforms_Klein

1.02 Lessons from Monogenic PD and Atypical Parkinsonism Studies_Lim

1.03 Lessons from PD and Atypical Parkinsonism GWAS_Mata

1.04 Discovery of the LRRK2 gene - A Personal Journey_Singleton

1.05 Understanding LRRK2 Protein Function - A Personal Journey_Alessi

1.06 Gene-Environment Interactions: Now and Future_Noyce

1.07 Genetics-Based Biomarkers: Now and Future_Sammler

1.08 Genetics-Based Therapeutics: Now and Future_Lin

1.09 Genetic testing in the clinic - Who should we test & what should we tell our patients?_Klein

DAY 2: Sunday, July 13, 2024

2.01 Approach to genetic testing and key points in genetic counselling for patients with movement disorders_Kumar

2.02 Approach to genetic testing and key points in genetic counselling for patients with movement disorders_Lin

2.03 How to interpret clinical genetic test reports and determine variant pathogenicity_Lohmann

2.04 Overview of WES/WGS bioinformatics pipeline and how to interpret WES/WGS variant calling file_Sarmiento

Recommended Readings

Effect Modification between Genes and Environment and Parkinsons Disease Risk.pdf

Pharmacotherapy for Disease Modification in Early Parkinson’s Disease: How Early Should We Be?

The Discovery of LRRK2 Mutations as a Cause of Parkinson’s Disease